| http://purl.uniprot.org/citations/17932104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17932104 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear receptor-mediated gene expression is regulated by corepressors and coactivators. In this study we demonstrate that prohibitin (PHB), a potential tumor suppressor, functions as a potent transcriptional corepressor for estrogen receptor alpha (ERalpha). Overexpression of PHB inhibits ERalpha transcriptional activity, whereas depletion of endogenous PHB increases the expression of ERalpha target genes in MCF-7 breast cancer cells. Chromatin immunoprecipitation experiments demonstrate that PHB is associated with the estrogen-regulated pS2 promoter in the absence of hormone and dissociates after estradiol treatment. We demonstrate that PHB interacts with the repressor of estrogen receptor activity (REA), a protein related to PHB, to form heteromers and enhance the protein stability of both corepressors. Interestingly, the corepressor activity of PHB is cross-squelched by the coexpression of REA (and vice versa), suggesting that PHB and REA repress transcription only when they are not paired. We further demonstrate that coiled-coil domains located in the middle of PHB and REA are responsible for their heteromerization, stabilization, and cross-squelching actions. Finally, ablation of PHB function in the mouse results in early embryonic lethality, whereas mice heterozygous for the PHB null allele exhibit a hyperproliferative mammary gland phenotype. Our results indicate that PHB functions as a transcriptional corepressor for ERalpha in vitro and in vivo, and that its heteromerization with REA acts as a novel mechanism to limit its corepressor activity."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2007-0400"xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "Feng Q."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "He B."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "Mukherjee A."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "Lydon J.P."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "O'Malley B.W."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "DeMayo F.J."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "Katzenellenbogen B.S."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/author | "Lonard D.M."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/pages | "344-360"xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/title | "A repressive role for prohibitin in estrogen signaling."xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/17932104 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17932104 |
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