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http://purl.uniprot.org/citations/17932313http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17932313http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The mechanism and role of angiotensin II-induced vascular endothelial injury is unclear. We examined the molecular mechanism of angiotensin (AII)-induced vascular endothelial injury and its significance for hypertensive diastolic heart failure.

Methods and results

We compared the effect of valsartan and amlodipine on Dahl salt-sensitive hypertensive rats (DS rats). Valsartan improved vascular endothelial dysfunction of DS rats more than amlodipine, by inhibiting endothelial apoptosis and eNOS uncoupling more. Moreover, valsartan inhibited vascular apoptosis signal-regulating kinase 1 (ASK1) more than amlodipine. Thus, AT1 receptor contributed to vascular endothelial apoptosis, eNOS uncoupling, and ASK1 activation of DS rats. Using ASK1(-/-) mice, we examined the causative role of ASK1 in endothelial apoptosis and eNOS uncoupling. AII infusion in wild-type mice markedly caused vascular endothelial apoptosis and eNOS uncoupling accompanied by vascular endothelial dysfunction, whereas these effects of AII were absent in ASK1(-/-) mice. Therefore, ASK1 participated in AII-induced vascular endothelial apoptosis and eNOS uncoupling. Using tetrahydrobiopterin, we found that eNOS uncoupling was involved in vascular endothelial dysfunction in DS rats with established diastolic heart failure.

Conclusions

AII-induced vascular endothelial apoptosis and eNOS uncoupling were mediated by ASK1 and contributed to vascular injury in diastolic heart failure of salt-sensitive hypertension."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.107.153692"xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Kataoka K."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Ogawa H."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Yamashita T."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Yamamoto E."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Matsuba S."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Ichijo H."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Shintaku H."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Kim-Mitsuyama S."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Tokutomi Y."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/author"Dong Y.F."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/pages"2569-2575"xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/title"Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure."xsd:string
http://purl.uniprot.org/citations/17932313http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/17932313http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17932313
http://purl.uniprot.org/citations/17932313http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17932313
http://purl.uniprot.org/uniprot/A0A8I6AEL0#attribution-8DAC25B06ECF677133CB9F51670A15D1http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/17932313
http://purl.uniprot.org/uniprot/D3ZW27#attribution-8DAC25B06ECF677133CB9F51670A15D1http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/17932313
http://purl.uniprot.org/uniprot/D3ZZH6#attribution-8DAC25B06ECF677133CB9F51670A15D1http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/17932313
http://purl.uniprot.org/uniprot/A0A8I6A280#attribution-8DAC25B06ECF677133CB9F51670A15D1http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/17932313
http://purl.uniprot.org/uniprot/#_D3ZW27-mappedCitation-17932313http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17932313
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