| http://purl.uniprot.org/citations/17932417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17932417 | http://www.w3.org/2000/01/rdf-schema#comment | "Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells that are the subject of intense investigation in regenerative medicine. In addition, MSCs possess immunomodulatory properties with therapeutic potential to prevent graft-versus-host disease (GvHD) in allogeneic hematopoietic cell transplantation. Indeed, MSCs can inhibit natural killer (NK) function, modulate dendritic cell maturation, and suppress allogeneic T-cell response. Here, we report that the nonclassic human leukocyte antigen (HLA) class I molecule HLA-G is responsible for the immunomodulatory properties of MSCs. Our data show that MSCs secrete the soluble isoform HLA-G5 and that such secretion is interleukin-10-dependent. Moreover, cell contact between MSCs and allostimulated T cells is required to obtain a full HLA-G5 secretion and, as consequence, a full immunomodulation from MSCs. Blocking experiments using neutralizing anti-HLA-G antibody demonstrate that HLA-G5 contributes first to the suppression of allogeneic T-cell proliferation and then to the expansion of CD4(+)CD25(high)FOXP3(+) regulatory T cells. Furthermore, we demonstrate that in addition to their action on the adaptive immune system, MSCs, through HLA-G5, affect innate immunity by inhibiting both NK cell-mediated cytolysis and interferon-gamma secretion. Our results provide evidence that HLA-G5 secreted by MSCs is critical to the suppressive functions of MSCs and should contribute to improving clinical therapeutic trials that use MSCs to prevent GvHD."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.org/dc/terms/identifier | "doi:10.1634/stemcells.2007-0554"xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Naji A."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Carosella E.D."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Rouas-Freiss N."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Borg C."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Favier B."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Tiberghien P."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Saas P."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Deschaseaux F."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Obert L."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Selmani Z."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Zidi I."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/author | "Gaiffe E."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/pages | "212-222"xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/title | "Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17932417 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17932417 |
| http://purl.uniprot.org/citations/17932417 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17932417 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9X9-mappedCitation-17932417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932417 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y0-mappedCitation-17932417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932417 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y1-mappedCitation-17932417 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932417 |