| http://purl.uniprot.org/citations/17932942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17932942 | http://www.w3.org/2000/01/rdf-schema#comment | "Some observations have suggested that cells from the central nervous system (CNS) could present exogenous antigens on major histocompatibility complex (MHC) class I molecules to CD8(+) T cells (a process called cross-presentation). Microglia are the major myeloid immunocompetent cells of the CNS. When activated, following the injury of the nervous parenchyma, they become fully competent antigen-presenting cells (APC) that prime CD4(+) T lymphocytes. We therefore tested the cross-presentation capacity of murine microglia. We report that a microglial cell line (C8-B4), neonatal microglia, and interestingly adult microglia cross-present soluble exogenous antigen (ovalbumin) to a OVA-specific CD8(+) T-cell hybridoma and cross-prime OVA-specific naive OT-1 CD8(+) T cells. In both these cases, C8-B4 and neonatal microglia cross-present OVA as well as peritoneal macrophages. Although cross-presentation by adult microglia is less efficient, it is increased by GM-CSF and CpG oligodeoxynucleotide (ODN) stimulation. Using microglial cells either exposed to an inhibitor of proteasome, lactacystin, or purified from TAP(-/-) mice, we demonstrate that the microglia cross-present antigen in proteasome- and TAP-dependant pathways, respectively. Last, microglia purified from adult mice injected intracerebrally with OVA efficiently stimulate OVA-specific CD8(+) T cells, thereby showing that microglia take up and process exogenous antigen into MHC class I in vivo. This first demonstration of the cross-presentation property of microglia offers novel therapeutic approaches to modulate CD8 T-cell responses in the brain."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.org/dc/terms/identifier | "doi:10.1002/glia.20565"xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Couez D."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Delneste Y."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Jeannin P."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Gascan H."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Guermonprez P."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Beauvillain C."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Scotet M."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Donnou S."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/author | "Jarry U."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/name | "Glia"xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/pages | "69-77"xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/title | "Neonatal and adult microglia cross-present exogenous antigens."xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/17932942 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17932942 |
| http://purl.uniprot.org/citations/17932942 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17932942 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-17932942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932942 |
| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-17932942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932942 |
| http://purl.uniprot.org/uniprot/#_Q3U543-mappedCitation-17932942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932942 |
| http://purl.uniprot.org/uniprot/#_Q62428-mappedCitation-17932942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932942 |
| http://purl.uniprot.org/uniprot/#_Q62429-mappedCitation-17932942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932942 |
| http://purl.uniprot.org/uniprot/#_Q64333-mappedCitation-17932942 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17932942 |