| http://purl.uniprot.org/citations/17933794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17933794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17933794 | http://www.w3.org/2000/01/rdf-schema#comment | "In this report, we investigate the C. elegans CBFbeta homologue, BRO-1. bro-1 mutants have a similar male-specific sensory ray loss phenotype to rnt-1 (the C. elegans homologue of the mammalian CBFbeta-interacting Runx factors), caused by failed cell divisions in the seam lineages. Our studies indicate that BRO-1 and RNT-1 form a cell proliferation-promoting complex, and that BRO-1 increases both the affinity and specificity of RNT-1-DNA interactions. Overexpression of bro-1, like rnt-1, leads to an expansion of seam cell number and co-overexpression of bro-1 and rnt-1 results in massive seam cell hyperplasia. Finally, we find that BRO-1 appears to act independently of RNT-1 in certain situations. These studies provide new insights into the function and regulation of this important cancer-associated DNA-binding complex in stem cells and support the view that Runx/CBFbeta factors have oncogenic potential."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.008276"xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.008276"xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Kohara Y."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Kohara Y."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Miwa Y."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Miwa Y."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Tanaka J."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Tanaka J."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Woollard A."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Woollard A."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Kagoshima H."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Kagoshima H."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Nimmo R."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Nimmo R."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Saad N."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/author | "Saad N."xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17933794 | http://purl.uniprot.org/core/name | "Development"xsd:string |