| http://purl.uniprot.org/citations/17934211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17934211 | http://www.w3.org/2000/01/rdf-schema#comment | "A strategy for the stable expression of proteins, or large protein fragments, from Chlamydia trachomatis into human cells was designed to identify bacterial epitopes endogenously processed and presented by HLA-B27. Fusion protein constructs in which the green fluorescent protein gene was placed at the 5'-end of the bacterial DNA primase gene or some of its fragments were transfected into B*2705-C1R cells. One of these constructs, including residues 90-450 of the bacterial protein, was stably and efficiently expressed. Mass spectrometry-based comparative analysis of HLA-B27-bound peptide pools led to identification of three HLA-B27 ligands differentially presented in the transfectant cells. Sequencing of these peptides confirmed that they were derived from the bacterial DNA primase. One of them, spanning residues 211-221, showed 55% sequence identity with a known self-ligand of HLA-B27 derived from its own molecule. The other two bacterial ligands, P-(112-121) and P-(112-122), were derived from the same region and differed in length by one residue at the C terminus. Both peptides showed >50% identity with multiple human protein sequences that possessed the optimal peptide motifs for HLA-B27 binding. Thus, expression of proteins from arthritogenic bacteria in HLA-B27-positive human cells allows identifying bacterial peptides that are endogenously processed and presented by HLA-B27 and show molecular mimicry with known self-ligands of this molecule and human proteins."xsd:string |
| http://purl.uniprot.org/citations/17934211 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m700386-mcp200"xsd:string |
| http://purl.uniprot.org/citations/17934211 | http://purl.uniprot.org/core/author | "Cragnolini J.J."xsd:string |
| http://purl.uniprot.org/citations/17934211 | http://purl.uniprot.org/core/author | "de Castro J.A."xsd:string |
| http://purl.uniprot.org/citations/17934211 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17934211 | http://purl.uniprot.org/core/name | "Mol Cell Proteomics"xsd:string |
| http://purl.uniprot.org/citations/17934211 | http://purl.uniprot.org/core/pages | "170-180"xsd:string |
| http://purl.uniprot.org/citations/17934211 | http://purl.uniprot.org/core/title | "Identification of endogenously presented peptides from Chlamydia trachomatis with high homology to human proteins and to a natural self-ligand of HLA-B27."xsd:string |
| http://purl.uniprot.org/citations/17934211 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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