| http://purl.uniprot.org/citations/17937501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17937501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17937501 | http://www.w3.org/2000/01/rdf-schema#comment | "A large number of alternative exons are spliced with tissue-specific patterns, but little is known about how such patterns have evolved. Here, we study the conservation of the neuron-specific splicing factors Nova1 and Nova2 and of the alternatively spliced exons they regulate in mouse brain. Whereas Nova RNA binding domains are 94% identical across vertebrate species, Nova-dependent splicing silencer and enhancer elements (YCAY clusters) show much greater divergence, as less than 50% of mouse YCAY clusters are conserved at orthologous positions in the zebrafish genome. To study the relation between the evolution of tissue-specific splicing and YCAY clusters, we compared the brain-specific splicing of Nova-regulated exons in zebrafish, chicken, and mouse. The presence of YCAY clusters in lower vertebrates invariably predicted conservation of brain-specific splicing across species, whereas their absence in lower vertebrates correlated with a loss of alternative splicing. We hypothesize that evolution of Nova-regulated splicing in higher vertebrates proceeds mainly through changes in cis-acting elements, that tissue-specific splicing might in some cases evolve in a single step corresponding to evolution of a YCAY cluster, and that the conservation level of YCAY clusters relates to the functions encoded by the regulated RNAs."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.0030173"xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Darnell R.B."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Darnell R.B."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Jelen N."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Jelen N."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Zivin M."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/author | "Zivin M."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/pages | "1838-1847"xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/pages | "1838-1847"xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/title | "Evolution of Nova-dependent splicing regulation in the brain."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/title | "Evolution of Nova-dependent splicing regulation in the brain."xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/17937501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17937501 |
| http://purl.uniprot.org/citations/17937501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17937501 |
| http://purl.uniprot.org/citations/17937501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17937501 |