| http://purl.uniprot.org/citations/17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17938254 | http://www.w3.org/2000/01/rdf-schema#comment | "The liver peptide hepcidin regulates iron absorption and recycling. Hemojuvelin (HJV) has a key role in hepcidin regulation, and its inactivation causes severe iron overload both in humans and in mice. Membrane HJV (m-HJV) acts as a coreceptor for bone morphogenetic proteins (BMPs), whereas soluble HJV (s-HJV) may down-regulate hepcidin in a competitive way interfering with BMP signaling. s-HJV is decreased by iron in vitro and increased by iron deficiency in vivo. However, the mechanisms regulating the 2 HJV isoforms remain unclear. Here we show that s-HJV originates from a furin cleavage at position 332-335. s-HJV is reduced in the cleavage mutant R335Q as well as in cells treated with a furin inhibitor, and increased in cells overexpressing exogenous furin, but not in cells overexpressing an inactive furin variant. Furin is up-regulated by iron deficiency and hypoxia in association with the stabilization of HIF-1alpha. Increased s-HJV in response to HIF-1alpha occurs during differentiation of murine muscle cells expressing endogenous Hjv. Our data are relevant to the mechanisms that relate iron metabolism to the hypoxic response. The release of s-HJV might be a tissue-specific mechanism, signaling the local iron requests of hypoxic skeletal muscles independently of the oxygen status of the liver."xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-07-100677"xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/author | "Silvestri L."xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/author | "Pagani A."xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/author | "Camaschella C."xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/pages | "924-931"xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/title | "Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis."xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/17938254 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17938254 |
| http://purl.uniprot.org/citations/17938254 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17938254 |
| http://purl.uniprot.org/uniprot/P09958#attribution-5B53436EC0D3B65C3748A1D9D17B7EEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/#_A8K466-mappedCitation-17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/#_A8K9M7-mappedCitation-17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/#_P09958-mappedCitation-17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/#_P23188-mappedCitation-17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/#_Q7TQ32-mappedCitation-17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/#_Q6ZVN8-mappedCitation-17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/#_Q8CIY1-mappedCitation-17938254 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/P09958 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/P23188 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/Q8CIY1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17938254 |
| http://purl.uniprot.org/uniprot/A8K466 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17938254 |