| http://purl.uniprot.org/citations/17940278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17940278 | http://www.w3.org/2000/01/rdf-schema#comment | "The Krüppel-like transcription factor ZBP-89 is a sequence-specific regulator that plays key roles in cellular growth and differentiation especially in endodermal and germ cell lineages. ZBP-89 shares with other members of the Sp-like family an overlapping sequence specificity for GC-rich sequences in the regulatory regions of multiple genes. Defining the mechanisms that govern the intrinsic function of ZBP-89 as well as its competitive and non-competitive functional interactions with other regulators is central to understand how ZBP-89 exerts its biological functions. We now describe that post-translational modification of ZBP-89 by multiple small ubiquitin-like modifier (SUMO) isoforms occurs at two conserved synergy control motifs flanking the DNA binding domain. Functionally sumoylation did not directly alter the ability of ZBP-89 to compete with other Sp-like factors from individual sites. At promoters bearing multiple response elements, however, this modification inhibited the functional cooperation between ZBP-89 and Sp1. Analysis of the properties of ZBP-89 in cellular contexts devoid of competing factors indicated that although on its own it behaves as a modest activator it potently synergizes with heterologous activators such as the glucocorticoid receptor. Notably we found that when conjugated to ZBP-89, SUMO exerts a strong inhibitory effect on such synergistic interactions through a critical conserved functional surface. By regulating higher order functional interactions, sumoylation provides a reversible post-translational mechanism to control the activity of ZBP-89."xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m708130200"xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/author | "Bai L."xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/author | "Brevig H."xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/author | "Iniguez-Lluhi J.A."xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/author | "Chupreta S."xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/author | "Merchant J.L."xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/pages | "36155-36166"xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/title | "Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89."xsd:string |
| http://purl.uniprot.org/citations/17940278 | http://purl.uniprot.org/core/volume | "282"xsd:string |
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