| http://purl.uniprot.org/citations/17942705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17942705 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17942705 | http://www.w3.org/2000/01/rdf-schema#comment | "SUMOylation of transcription factors often attenuates transcription activity. This regulation of protein activity allows more diversity in the control of gene expression. Interferon regulatory factor-1 (IRF-1) was originally identified as a regulator of IFN-alpha/beta, and its expression is induced by viral infection or IFN stimulation. Accumulating evidence supports the theory that IRF-1 functions as a tumor suppressor and represses the transformed phenotype. Here we report that the level of SUMOylated IRF-1 is elevated in tumors. Site-directed mutagenesis experiments disclose that the SUMOylation sites of IRF-1 are identical to the major ubiquitination sites. Consequently, SUMOylated IRF-1 displays enhanced resistance to degradation. SUMOylation of IRF-1 attenuates its transcription activity, and SUMOylated IRF-1 inhibits apoptosis by repression of its transcriptional activity. These data support a mechanism whereby SUMOylation of IRF-1 inactivates its tumor suppressor function, which facilitates resistance to the immune response."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0609852104"xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0609852104"xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lee S.-H."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lee S.-H."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lee J.-H."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lee J.-H."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Park J."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Park K."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Park K."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lee E.-J."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lee E.-J."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Rho S.B."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Rho S.B."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Seo Y.-J."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Seo Y.-J."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lim S.-N."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/author | "Lim S.-N."xsd:string |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17942705 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |