| http://purl.uniprot.org/citations/17945327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17945327 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17945327 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that BMRF-2, an Epstein-Barr virus (EBV) glycoprotein, binds to beta1 family integrins and is important for EBV infection of polarized oral epithelial cells. To further study the functions of BMRF-2, we constructed a recombinant EBV that lacks BMRF-2 expression by homologous recombination in B95-8 cells. We found that lack of BMRF-2 resulted in about 50% reduction of EBV attachment to oral epithelial cells, but not to B lymphocytes, suggesting that BMRF-2 is critical for EBV infection in oral epithelial cells, but not in B lymphocytes. In polarized oral epithelial cells, infection rate of the recombinant EBV virus was about 4-to 8-fold lower than the wild-type B95-8 virus. Cell adhesion assays using the BMRF-2 RGD peptide and its RGE and AAA mutants showed that the RGD motif is critical for BMRF-2 binding to integrins. These data are consistent with our previous observation that interactions between EBV BMRF-2 and integrins are critical for infection of oral epithelial cells with EBV."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2007.09.012"xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2007.09.012"xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Berline J."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Berline J."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Herrera R."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Herrera R."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Palefsky J.M."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Palefsky J.M."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Tugizov S.M."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Tugizov S.M."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Xiao J."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/author | "Xiao J."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/pages | "430-442"xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/pages | "430-442"xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/title | "The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/title | "The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/volume | "370"xsd:string |
| http://purl.uniprot.org/citations/17945327 | http://purl.uniprot.org/core/volume | "370"xsd:string |