| http://purl.uniprot.org/citations/17947428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17947428 | http://www.w3.org/2000/01/rdf-schema#comment | "In Caenorhabditis elegans, sex is determined by the opposing actions of X-signal elements (XSEs) and autosomal signal elements (ASEs), which communicate the ratio of X chromosomes to sets of autosomes (X:A signal). This study delves more deeply into the mechanism by which XSEs transmit X chromosome dose. We determined the relative contributions of individual XSEs to the X:A signal and showed the order of XSE strength to be sex-1 > sex-2 > fox-1 > ceh-39 >/= region 1 XSE. sex-1 exerts a more potent influence on sex determination and dosage compensation than any other XSE by functioning in two separate capacities in the pathway: sex-1 acts upstream as an XSE to repress xol-1 and downstream as an activator of hermaphrodite development and dosage compensation. Furthermore, the process of dosage compensation affects expression of the very XSEs that control it; XSEs become fully dosage compensated once sex is determined. The X:A signal is then equivalent between XO and XX animals, causing sexual differentiation to be controlled by genes downstream of xol-1 in the sex-determination pathway. Prior to the onset of dosage compensation, the difference in XSE expression between XX and XO embryos appears to be greater than twofold, making X chromosome counting a robust process."xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.107.078071"xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/author | "Meyer B.J."xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/author | "Gladden J.M."xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/author | "Farboud B."xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/pages | "1639-1654"xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/title | "Revisiting the X:A signal that specifies Caenorhabditis elegans sexual fate."xsd:string |
| http://purl.uniprot.org/citations/17947428 | http://purl.uniprot.org/core/volume | "177"xsd:string |
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