| http://purl.uniprot.org/citations/17947644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17947644 | http://www.w3.org/2000/01/rdf-schema#comment | "Tapasin organizes the peptide-loading complex (PLC) by recruiting peptide-receptive MHC class I (MHC-I) and accessory chaperones to the N-terminal regions of the TAP subunits TAP1 and TAP2. Despite numerous studies have shown that the formation of the PLC is essential to facilitate proper MHC-I loading, the molecular architecture of this complex is still highly controversial. We studied the stoichiometry of the PLC by blue native-PAGE in combination with Ab-shift assays and found that TAP/tapasin complexes exist at steady state as a mixture of two distinct oligomers of 350 and 450 kDa. Only the higher m.w. complex contains MHC-I and disulfide-linked tapasin/ER60 conjugates. Moreover, we show for the first time to our knowledge that the fully assembled PLC comprises two tapasin, two ER60, but only one complex of MHC-I and calreticulin. Based hereon we postulate that the TAP subunits alternate in the recruitment and loading of a single MHC-I."xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.9.5717"xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/author | "Leonhardt R.M."xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/author | "Knittler M.R."xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/author | "Rufer E."xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/pages | "5717-5727"xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/title | "Molecular architecture of the TAP-associated MHC class I peptide-loading complex."xsd:string |
| http://purl.uniprot.org/citations/17947644 | http://purl.uniprot.org/core/volume | "179"xsd:string |
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