| http://purl.uniprot.org/citations/17951978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17951978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17951978 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiotensin II (AII) has been reported to induce leukocyte adhesion to endothelium through up-regulation of P-selectin surface expression. However, the underlying molecular and cellular mechanisms remain unknown. P-selectin is stored in Weibel-Palade bodies (WPBs), large secretory granules, in endothelial cells. In this study, we examined the role of protein kinase D (PKD), a newly identified regulator of protein transport, in AII-induced WPB exocytosis and the resultant P-selectin surface expression. We demonstrated that PKD2 was rapidly activated by AII in endothelial cells through phosphorylation of the activation loop at Ser744/748. AII-induced PKD2 activation correlated with increased P-selectin surface expression. Furthermore, AII-regulated PKD2 activation is protein kinase C (PKC) alpha-dependent. Importantly, knock-down of either PKD2 or PKCalpha expression inhibited AII-mediated P-selectin surface expression and monocyte adhesion. Our findings provide the first evidence that stimulation of P-selectin surface expression via PKCalpha-dependent PKD2 activation could be an important mechanism in the early onset of AII-initiated endothelial adhesiveness."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.org/dc/terms/identifier | "doi:10.1254/jphs.fp0070858"xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.org/dc/terms/identifier | "doi:10.1254/jphs.fp0070858"xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Ge X."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Ge X."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Fu J."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Liang M."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Liang M."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Low B."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/author | "Low B."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/name | "J. Pharmacol. Sci."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/name | "J. Pharmacol. Sci."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/pages | "168-176"xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/pages | "168-176"xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/title | "Angiotensin II directly triggers endothelial exocytosis via protein kinase C-dependent protein kinase D2 activation."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/title | "Angiotensin II directly triggers endothelial exocytosis via protein kinase C-dependent protein kinase D2 activation."xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/17951978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17951978 |
| http://purl.uniprot.org/citations/17951978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17951978 |