| http://purl.uniprot.org/citations/17954695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17954695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17954695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17954695 | http://www.w3.org/2000/01/rdf-schema#comment | "Multistep genetic alteration is required for methicillin-resistant Staphylococcus aureus (MRSA) to achieve the level of vancomycin resistance of vancomycin-intermediate S. aureus (VISA). In the progression of vancomycin resistance, strains with heterogeneous vancomycin resistance, designated hetero-VISA, are observed. In studying the whole-genome sequencing of the representative hetero-VISA strain Mu3 and comparing it with that of closely related MRSA strains Mu50 (VISA) and N315 (vancomycin-susceptible S. aureus [VSSA]), we identified a mutation in the response regulator of the graSR two-component regulatory system. Introduction of mutated graR, designated graR*, but not intact graR, designated graRn, could convert the hetero-VISA phenotype of Mu3 into a VISA phenotype which was comparable to that of Mu50. The same procedure did not appreciably increase the vancomycin resistance of VSSA strain N315, indicating that graR* expression was effective only in the physiological milieu of hetero-VISA cell to achieve a VISA phenotype. Interestingly, the overexpression of graR* increased the daptomycin MICs in both Mu3 and N315 and decreased the oxacillin MIC in N315."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.org/dc/terms/identifier | "doi:10.1128/aac.00534-07"xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.org/dc/terms/identifier | "doi:10.1128/aac.00534-07"xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.org/dc/terms/identifier | "doi:10.1128/aac.00534-07"xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Cui L."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Cui L."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Cui L."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Hiramatsu K."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Hiramatsu K."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Hiramatsu K."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Matsuo M."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Neoh H.-M."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Neoh H.-M."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Neoh H.-M."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Takeuchi F."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Takeuchi F."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Takeuchi F."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Yuzawa H."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Yuzawa H."xsd:string |
| http://purl.uniprot.org/citations/17954695 | http://purl.uniprot.org/core/author | "Yuzawa H."xsd:string |