| http://purl.uniprot.org/citations/17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17955445 | http://www.w3.org/2000/01/rdf-schema#comment | "African trypanosomiasis encompasses diseases caused by pathogenic trypanosomes, infecting both humans and animals. In the present article, we dissected the possible role of members of the interleukin (IL)-12 family during infection with Trypanosoma brucei brucei and Trypanosoma evansi in mice. IL-12p35(-/-), IL-12p40(-/-), and IL-12p35(-/-)/p40(-/-) mice were susceptible to both pathogens, as was demonstrated by the increased mortality among these mice, compared with wild-type C57BL/6 mice. The different IL-12p70(-/-) mouse strains showed similar mortality kinetics, suggesting that IL-12p70--but not the IL-12p80 homodimer or IL-23--plays a crucial role in survival. Although there were similar plasma levels of immunoglobulin (Ig) M and IgG2a in IL-12-deficient mice and wild-type mice, interferon (IFN)-gamma production, especially during early infection, was severely impaired in all IL-12p70(-/-) mouse strains, demonstrating an IL-12p70-dependent mechanism for IFN- gamma production. Because IFN- gamma receptor-deficient mice (IFN-gamma R(-/-)) were also highly susceptible to both Trypanosoma species, IL-12p70-dependent IFN-gamma production seems to be the important mechanism involved in resistance against both pathogens."xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.org/dc/terms/identifier | "doi:10.1086/521681"xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/author | "Atkinson R.A."xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/author | "Brombacher F."xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/author | "Magez S."xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/author | "Barkhuizen M."xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/pages | "1253-1260"xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/title | "Interleukin-12p70-dependent interferon- gamma production is crucial for resistance in African trypanosomiasis."xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://purl.uniprot.org/core/volume | "196"xsd:string |
| http://purl.uniprot.org/citations/17955445 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17955445 |
| http://purl.uniprot.org/citations/17955445 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17955445 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_E9PX11-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_Q540M5-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_F8WI71-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_P01580-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_Q3ZAX5-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |
| http://purl.uniprot.org/uniprot/#_Q3U8T2-mappedCitation-17955445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17955445 |