| http://purl.uniprot.org/citations/17957786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17957786 | http://www.w3.org/2000/01/rdf-schema#comment | "The BALB/c-IL10 null mouse strain develops colitis and colitis-associated adenocarcinomas, and is a model for idiopathic inflammatory bowel disease. We tested the hypotheses that (i) azoxymethane (AOM), a carcinogen that targets the colon, synergizes with the colonic inflammation inherent in the BALB/c-IL10 null mouse resulting in an increase in incidence, multiplicity and/or progression of AOM-induced tumors or colitis-associated adenocarcinomas; and (ii) prior infection with Helicobacter hepaticus, a common enterohepatic bacterial pathogen in many research mouse colonies, increases the incidence, multiplicity and/or progression of AOM-induced colon tumors or colitis-associated adenocarcinomas in the BALB/c-IL10 null mouse. We show that, within the timeframe examined, AOM-induced colon tumors in the BALB/c-IL10 null mouse were grossly and microscopically similar in appearance to AOM-induced colon tumors in the wild type BALB/cJ mouse. No colitis-associated adenocarcinomas were identified. Infection with H. hepaticus prior to AOM-treatment also did not result in colitis-associated adenocarcinomas but did result in a significant increase in the incidence of AOM-induced colon tumors relative to AOM treatment alone. The AOM-induced adenomas were predominantly exophytic and nodular or polypoid and localized to the distal colon. These results suggest that H. hepaticus promotes AOM-induced tumorigenesis in the BALB/c-IL10 null mouse."xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.23175"xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/author | "Fox J.G."xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/author | "Schauer D.B."xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/author | "Nagamine C.M."xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/author | "Rogers A.B."xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/pages | "832-838"xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/title | "Helicobacter hepaticus promotes azoxymethane-initiated colon tumorigenesis in BALB/c-IL10-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/17957786 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17957786 |
| http://purl.uniprot.org/citations/17957786 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17957786 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-17957786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17957786 |
| http://purl.uniprot.org/uniprot/#_Q3U879-mappedCitation-17957786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17957786 |
| http://purl.uniprot.org/uniprot/#_P18893-mappedCitation-17957786 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17957786 |
| http://purl.uniprot.org/uniprot/A0A7R8GUQ3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17957786 |
| http://purl.uniprot.org/uniprot/P18893 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17957786 |
| http://purl.uniprot.org/uniprot/Q3U879 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17957786 |