| http://purl.uniprot.org/citations/17959600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17959600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17959600 | http://www.w3.org/2000/01/rdf-schema#comment | "Lithium (Li(+)) has been used to treat mood affect disorders, including bipolar, for decades. This drug is neuroprotective and has several identified molecular targets. However, it has a narrow therapeutic range and the one or more underlying mechanisms of its therapeutic action are not understood. Here we describe a pharmacogenetic study of Li(+) in the nematode Caenorhabditis elegans. Exposure to Li(+) at clinically relevant concentrations throughout adulthood increases survival during normal aging (up to 46% median increase). Longevity is extended via a novel mechanism with altered expression of genes encoding nucleosome-associated functions. Li(+) treatment results in reduced expression of the worm ortholog of LSD-1 (T08D10.2), a histone demethylase; knockdown by RNA interference of T08D10.2 is sufficient to extend longevity ( approximately 25% median increase), suggesting Li(+) regulates survival by modulating histone methylation and chromatin structure."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m705028200"xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m705028200"xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Lithgow G.J."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Lithgow G.J."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Melov S."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Melov S."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Vantipalli M.C."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Vantipalli M.C."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Hubbard A.E."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Hubbard A.E."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Killilea D.W."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "Killilea D.W."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "McColl G."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/author | "McColl G."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/pages | "350-357"xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/pages | "350-357"xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/title | "Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17959600 | http://purl.uniprot.org/core/title | "Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans."xsd:string |