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http://purl.uniprot.org/citations/17962208http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17962208http://www.w3.org/2000/01/rdf-schema#comment"

Background

The aim of this study is to provide an expression profile of ErbB/HER ligands in breast cancer. We analysed the relationships with their receptors, the bio-pathological features and prognosis.

Patients and methods

Epidermal growth factor (EGF), transforming growth factor-alpha (TGFalpha), amphiregulin (AREG), betacellulin (BTC), heparin-binding EGF-like growth factor (HB-EGF), epiregulin (EREG) and neuregulins1-4 (NRG1-4) were quantified in 363 tumours by real-time reverse transcription-polymerase chain reaction using TaqMan probes.

Results

Ligands were detected in 80%-96% of the cases, except NRG3 (42%) and EREG (45.5%). At least one ligand was expressed in 304 cases (cut-off: upper quartile). Almost all combinations of receptor and ligand co-expressions were observed, but TGFalpha is preferentially expressed in tumours co-expressing EGFR/HER3, NRG3 in those co-expressing EGFR/HER4, AREG and EREG in those co-expressing HER2/HER4. EGF and AREG were associated with estradiol receptors, small tumour size, low histoprognostic grading, high HER4 levels. TGFalpha, HB-EGF and NRG2 were negatively related to these parameters. In Cox univariate analyses, EGF was a prognostic factor.

Conclusion

Our study demonstrates that (i) ErbB/HER ligands, including BTC and EREG, are expressed in most breast cancers; and (ii) TGFalpha, HB-EGF and NRG2 high expressions are related to the biological aggressiveness of the tumours."xsd:string
http://purl.uniprot.org/citations/17962208http://purl.org/dc/terms/identifier"doi:10.1093/annonc/mdm431"xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/author"Lhotellier V."xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/author"Peyrat J.P."xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/author"Hornez L."xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/author"Revillion F."xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/author"Bonneterre J."xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/name"Ann Oncol"xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/pages"73-80"xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/title"ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis."xsd:string
http://purl.uniprot.org/citations/17962208http://purl.uniprot.org/core/volume"19"xsd:string
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