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| http://purl.uniprot.org/citations/17963692 | http://www.w3.org/2000/01/rdf-schema#comment | "N-WASP (Neural Wiskott Aldrich Syndrome Protein) regulates actin polymerization by activating the Arp2/3 complex and promotes the formation of actin-rich structures such as filopodia. Such actin-rich structures play critical roles in cell adhesion and cell motility. Analysis of the adhesion properties of N-WASP+/+ and N-WASP-/-mouse embryonic fibroblasts to extracellular matrix proteins revealed that N-WASP is critical for cell adhesion to fibronectin. There was no significant difference in the localization of paxillin in the two cell lines, however the vinculin patches in WASP+/+ cells were thicker and more prominent than those in N-WASP-/-cells. The beta1 integrins in N-WASP+/+ cells were found in large clusters, while beta1 integrins were more dispersed in N-WASP-/- cells. The N-WASP-/-cells migrated more rapidly than N-WASP+/+ cells in a scratch migration assay. Thus, our data suggest that N-WASP deficiency leads to reduced adhesion to fibronectin and increased cell motility."xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.10.086"xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/author | "Misra A."xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/author | "Thanabalu T."xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/author | "Lim R.P."xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/pages | "908-912"xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/title | "N-WASP plays a critical role in fibroblast adhesion and spreading."xsd:string |
| http://purl.uniprot.org/citations/17963692 | http://purl.uniprot.org/core/volume | "364"xsd:string |
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