| http://purl.uniprot.org/citations/17966039 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17966039 | http://www.w3.org/2000/01/rdf-schema#comment | "We have reported that Sjögren's syndrome (SS) patients with enlarged exocrine glands (EEG) formerly referred to as Mikulicz's disease were defective with Fas-ligand (FasL) expression in PBL and lacrimal glands (LGs). To investigate the mechanisms of reduced FasL expression in SS patients with EEG, FasL mRNA expression level was determined using real-time PCR. The FasL gene promoter region (from - 1197 to - 3) was also amplified using PCR and specific primers. Expression of the FasL mRNA in the LGs and PBLs of three SS patients with EEG was significantly decreased. Direct sequencing revealed a heterozygous point mutation ( - 259T/C) in the FasL gene promoter region in one SS patient with EEG. A luminescent beta-galactosidase (beta-gal) reporter assay using a pbetagal Enhancer Vector demonstrated that beta-gal activity from the vector including the mutant ( - 259C) FasL (pbetagal/mFasL) gene promoter region (735 +/-42) was similar (p = 0.13) to that from a pbetagal Enhancer Vector without the gene promoter region (603 +/-66). On the other hand, the beta-gal activity was significantly lower (p < 0.0001) than that from a vector including the wild-type ( - 259T) FasL (pbetagal/wFasL) (3226 +/-148). In conclusion, the down-regulation of FasL in SS patients with EEG may be due to transcriptional regulation, and the point mutation at - 259T/C in the FasL gene promoter region may lead to the down-regulation of FasL mRNA expression and the lymphoproliferative process observed in SS patients with EEG."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.org/dc/terms/identifier | "doi:10.1080/08916930701580320"xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/author | "Matsumoto Y."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/author | "Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/author | "Takeuchi T."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/author | "Tsubota K."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/author | "Tsuzaka K."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/name | "Autoimmunity"xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/pages | "497-502"xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/title | "Down-regulation of Fas-ligand mRNA in Sjogren's syndrome patients with enlarged exocrine glands."xsd:string |
| http://purl.uniprot.org/citations/17966039 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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