| http://purl.uniprot.org/citations/17968008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17968008 | http://www.w3.org/2000/01/rdf-schema#comment | "Thalamocortical in vivo and in vitro function was studied in mice lacking P/Q-type calcium channels (Cav2.1), in which N-type calcium channels (Cav2.2) supported central synaptic transmission. Unexpectedly, in vitro patch recordings from thalamic neurons demonstrated no gamma-band subthreshold oscillation, and voltage-sensitive dye imaging demonstrated an absence of cortical gamma-band-dependent columnar activation involving cortical inhibitory interneuron activity. In vivo electroencephalogram recordings showed persistent absence status and a dramatic reduction of gamma-band activity. Pharmacological block of T-type calcium channels (Cav3), although not noticeably affecting normal control animals, left the knockout mice in a coma-like state. Hence, although N-type calcium channels can rescue P/Q-dependent synaptic transmission, P/Q calcium channels are essential in the generation of gamma-band activity and resultant cognitive function."xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0707945104"xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/author | "Choi S."xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/author | "Shin H.S."xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/author | "Llinas R.R."xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/author | "Urbano F.J."xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/pages | "17819-17824"xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/title | "Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice."xsd:string |
| http://purl.uniprot.org/citations/17968008 | http://purl.uniprot.org/core/volume | "104"xsd:string |
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