| http://purl.uniprot.org/citations/17970752 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17970752 | http://www.w3.org/2000/01/rdf-schema#comment | "Upstream stimulatory factor and TFII-I are ubiquitously expressed helix-loop-helix transcription factors that interact with E-box sequences and or initiator elements. We previously demonstrated that upstream stimulatory factor is an activator of beta-globin gene expression whereas TFII-I is a repressor. In the present study, we demonstrate that upstream stimulatory factor interacts with the coactivator p300 and that this interaction is restricted to erythroid cells expressing the adult beta-globin gene. Furthermore, we demonstrate that Suz12, a component of the polycomb repressor complex 2, is recruited to the beta-globin gene. Reducing expression of Suz12 significantly activates beta-globin gene expression in an erythroid cell line with an embryonic phenotype. Suz12 also interacts with the adult beta-globin gene during early stages of erythroid differentiation of mouse embryonic stem cells. Our data suggest that TFII-I contributes to the recruitment of the polycomb repressor complex 2 complex to the beta-globin gene. Together, these data demonstrate that the antagonistic activities of upstream stimulatory factor and TFII-I on beta-globin gene expression are mediated at least in part by protein complexes that render the promoter associated chromatin accessible or inaccessible for the transcription complex."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2007.06128.x"xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/author | "Moghimi B."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/author | "Anantharaman A."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/author | "Bungert J."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/author | "Crusselle-Davis V.J."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/author | "Dodev T."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/pages | "6065-6073"xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/title | "Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor."xsd:string |
| http://purl.uniprot.org/citations/17970752 | http://purl.uniprot.org/core/volume | "274"xsd:string |
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