| http://purl.uniprot.org/citations/17971048 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17971048 | http://www.w3.org/2000/01/rdf-schema#comment | "This study is an extension to previously published work that has linked variation in the human leukocyte antigen (HLA) class I region with susceptibility to multiple sclerosis (MS) in Australians from the Island State of Tasmania. Single nucleotide polymorphism (SNP) mapping was performed on an 865-kb candidate region (D6S1683-D6S265) in 166 Tasmanian MS families, and seven candidate genes [ubiquitin D (UBD), olfactory receptor 2H3 (OR2H3), gamma-aminobutyric acid B receptor 1 (GABBR1), myelin oligodendrocyte glycoprotein (MOG), HLA-F, HLA complex group 4 (HCG4) and HLA-G] were resequenced. SNPs tagging the extended MS susceptibility haplotype were genotyped in an independent sample of 356 Australian MS trios and SNPs in the MOG gene were significantly over-transmitted to MS cases. We identified significant effects on MS susceptibility of HLA-A*2 (OR: 0.51; P = 0.05) and A*3 (OR: 2.85; P = 0.005), and two coding polymorphisms in the MOG gene (V145I: P = 0.01, OR: 2.2; V142L: P = 0.04, OR: 0.45) after full conditioning on HLA-DRB1. We have therefore identified plausible candidates for the causal MS susceptibility allele, and although not conclusive at this stage, our data provide suggestive evidence for multiple class I MS susceptibility genes."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1399-0039.2007.00962.x"xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Foote S.J."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Field J."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Bahlo M."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Speed T.P."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Johnson L.J."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Booth D."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Taylor B.V."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Tait B.D."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Varney M.D."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Butzkueven H."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Kilpatrick T.J."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Rubio J.P."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Stankovich J."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Stewart G.J."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Jensen C.J."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Heard R."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/author | "Burfoot R.K."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/pages | "42-50"xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/title | "SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians."xsd:string |
| http://purl.uniprot.org/citations/17971048 | http://purl.uniprot.org/core/volume | "71"xsd:string |