| http://purl.uniprot.org/citations/17974976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17974976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17974976 | http://www.w3.org/2000/01/rdf-schema#comment | "HiNF-P and its cofactor p220(NPAT) are principal factors regulating histone gene expression at the G(1)-S phase cell cycle transition. Here, we have investigated whether HiNF-P controls other cell cycle- and cancer-related genes. We used cDNA microarrays to monitor responsiveness of gene expression to small interfering RNA-mediated depletion of HiNF-P. Candidate HiNF-P target genes were examined for the presence of HiNF-P recognition motifs, in vitro HiNF-P binding to DNA, and in vivo association by chromatin immunoprecipitations and functional reporter gene assays. Of 177 proliferation-related genes we tested, 20 are modulated in HiNF-P-depleted cells and contain putative HiNF-P binding motifs. We validated that at least three genes (i.e., ATM, PRKDC, and CKS2) are HiNF-P dependent and provide data indicating that the DNA damage response is altered in HiNF-P-depleted cells. We conclude that, in addition to histone genes, HiNF-P also regulates expression of nonhistone targets that influence competency for cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-1560"xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-1560"xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Stein G.S."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Stein G.S."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Stein J.L."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "van Wijnen A.J."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Medina R."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Medina R."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Miele-Chamberland A."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Miele-Chamberland A."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Xie R.-L."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "Xie R.-L."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "van der Deen M."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/author | "van der Deen M."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/pages | "10334-10342"xsd:string |
| http://purl.uniprot.org/citations/17974976 | http://purl.uniprot.org/core/pages | "10334-10342"xsd:string |