| http://purl.uniprot.org/citations/17976533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17976533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17976533 | http://www.w3.org/2000/01/rdf-schema#comment | "In the human genome there are three genes encoding RhoGAPs that contain the START (steroidogenic acute regulatory protein (StAR)-related lipid transfer)-domain. START-GAP3/DLC3 is a tumor suppressor gene similar to two other human START-GAPs known as DLC1 or DLC2. Although expression of START-GAP3/DLC3 inhibits the proliferation of cancer cells, its molecular function is not well understood. In this study we carried out biochemical characterization of START-GAP3/DLC3, and explored the effects of its expression on cell morphology and intracellular localization. We found that START-GAP3/DLC3 serves as a stimulator of PLCdelta1 and as a GAP for both RhoA and Cdc42 in vitro. Moreover, we found that the GAP activity is responsible for morphological changes. The intracellular localization of endogenous START-GAP3/DLC3 was explored by immunocytochemistry and was revealed in focal adhesions. These results indicate that START-GAP3/DLC3 has characteristics similar to other START-GAPs and the START-GAP family seems to share common characteristics."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.10.052"xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.10.052"xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Kawai K."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Kawai K."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Yagisawa H."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Yagisawa H."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Kiyota M."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Kiyota M."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Deki Y."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Deki Y."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Seike J."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/author | "Seike J."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/pages | "783-789"xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/pages | "783-789"xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/title | "START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/title | "START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology."xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/volume | "364"xsd:string |
| http://purl.uniprot.org/citations/17976533 | http://purl.uniprot.org/core/volume | "364"xsd:string |