| http://purl.uniprot.org/citations/17977828 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17977828 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of immunoglobulin-secreting plasma cells from B cells is a tightly regulated process controlled by the action of a number of transcription factors. In particular, the transcription factor Blimp-1 is a key positive regulator of plasmacytic differentiation via its ability to suppress expression of genes involved in the mature B cell program. The transcription factor Ets-1 is a negative regulator of plasmacytic differentiation, as indicated by the development of increased numbers of IgM-secreting plasma cells in Ets-1 knock-out mice. We have previously shown that Ets-1-deficient B cells undergo enhanced differentiation into IgM-secreting plasma cells in response to Toll-like receptor 9 (TLR9) signaling. We now explore the mechanism by which Ets-1 limits differentiation downstream of TLR9. Our results indicate that Ets-1 physically interacts with Blimp-1, which leads to a block in Blimp-1 DNA binding activity and a reduction in the ability of Blimp-1 to repress target genes without interfering with Blimp-1 protein levels. In addition, we show that Ets-1 induces the expression of several target genes that are repressed by Blimp-1, including Pax-5. These results reveal a previously unknown mechanism for the control of Blimp-1 activity by Ets-1 and suggest that expression of Ets-1 must be down-regulated before plasmacytic differentiation can occur."xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m705262200"xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/author | "John S.A."xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/author | "Garrett-Sinha L.A."xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/author | "Clements J.L."xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/author | "Russell L.M."xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/pages | "951-962"xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/title | "Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1."xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/17977828 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17977828 |
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