| http://purl.uniprot.org/citations/17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17977914 | http://www.w3.org/2000/01/rdf-schema#comment | "The induction of cellular acquired thermal tolerance (ATT) during heat acclimation (HA) in humans is not well described. This study determined whether exercise-HA modifies the human heat shock protein (HSP)72 and HSP90 responses and whether changes are correlated with physiological adaptations to HA. Using a 10-day HA protocol comprising daily exercise (treadmill walking) in a hot environment (T(a) = 49 degrees C, 20% RH), we analyzed baseline and ex vivo heat-induced expression of HSP72 and HSP90 in peripheral blood mononuclear cells (PBMCs) isolated prior to exercise from eight subjects on day 1 and 10 of the HA protocol. Classical physiological responses to HA were observed, including significantly reduced heart rate and core body temperature, and significantly increased sweating rate. Baseline levels of HSP72 and HSP90 were significantly increased following acclimation by 17.7 +/- 6.1% and 21.1 +/-6.5%, respectively. Ex vivo induction of HSP72 in PBMCs exposed to heat shock (43 degrees C) was blunted on day 10 compared with day 1. A correlation was identified (r(2) = 0.89) between changes in core temperature elevation and ex vivo HSP90 responses to heat shock between days 1 and 10, indicating that volunteers demonstrating the greatest physiological HA tended to exhibit the greatest blunting of ex vivo HSP induction in response to heat shock. In summary, 1) exercise-HA resulted in increased baseline levels of HSP72 and HSP90, 2) ex vivo heat inducibility of HSP72 was blunted after HA, and 3) volunteers demonstrating the greatest physiological HA tended to exhibit the greatest blunting of ex vivo HSP induction in response to heat shock. These data demonstrate that physiological adaptations in humans undergoing HA are accompanied by both increases in baseline levels and changes in regulation of cytoprotective HSPs."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00532.2007"xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/author | "He J.R."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/author | "Singh I.S."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/author | "Hasday J.D."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/author | "McClung J.P."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/author | "Montain S.J."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/author | "Cheuvront S.N."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/author | "Sawka M.N."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/name | "Am J Physiol Regul Integr Comp Physiol"xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/pages | "R185-91"xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/title | "Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells."xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/17977914 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17977914 |
| http://purl.uniprot.org/citations/17977914 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17977914 |
| http://purl.uniprot.org/uniprot/#_A0A1U9X7W4-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |
| http://purl.uniprot.org/uniprot/#_B4DFN9-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |
| http://purl.uniprot.org/uniprot/#_B4DNT8-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |
| http://purl.uniprot.org/uniprot/#_B4DVU9-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |
| http://purl.uniprot.org/uniprot/#_B4E388-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |
| http://purl.uniprot.org/uniprot/#_B4DNV4-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |
| http://purl.uniprot.org/uniprot/#_B4DNX1-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |
| http://purl.uniprot.org/uniprot/#_B4DTA5-mappedCitation-17977914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977914 |