| http://purl.uniprot.org/citations/17977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17977916 | http://www.w3.org/2000/01/rdf-schema#comment | "The present study was designed to determine ANG peptide content [ANG I, ANG II, ANG-(1-7)], ACE2 mRNA, and the immunocytochemical distribution of ANG-(1-7) and ACE2 in the uteroembryonic unit during early and late gestation in Sprague-Dawley rats and in a rat model of pregnancy-induced hypertension, the reduced uterine perfusion pressure (RUPP) model. At early pregnancy ANG-(1-7) and ACE2 staining were localized in the primary and secondary decidual zone and luminal and glandular epithelial cells. During late gestation, ANG-(1-7) and ACE2 staining was visualized in the labyrinth placenta and amniotic and yolk sac epithelium. Uterine ANG II concentration at early pregnancy was significantly decreased by 21-55% in the implantation and interimplantation sites compared with virgin rats, whereas ANG-(1-7) levels were maintained at prepregnancy levels. At late gestation, uterine concentrations of ANG I and ANG II were significantly increased (30% and 25%, respectively). In RUPP animals, ANG-(1-7) concentration is significantly reduced in the uterus (181 +/- 16 vs. 372 +/-74 fmol/g of tissue) and placenta (143 +/- 26 vs. 197 +/-20 fmol/g of tissue). ACE2 mRNA increased in the uterus of early pregnant compared with virgin rats, yet within the implantation site it was downregulated. At late pregnancy, ACE2 mRNA is elevated by 58% in the uterus and decreased by 59% in RUPP animals. The regulation of ANG-(1-7) and ACE2 in early and late pregnancy supports the hypothesis that ANG-(1-7) and ACE2 may act as a local autocrine/paracrine regulator throughout pregnancy, participating in the early (angiogenesis, apoptosis, and growth) and late (uteroplacental blood flow) events of pregnancy."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00514.2007"xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Ferrario C.M."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Joyner J."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Stovall K."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Merrill D.C."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Brosnihan K.B."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Valdes G."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Neves L.A."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/author | "Gallagher P.E."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/name | "Am J Physiol Regul Integr Comp Physiol"xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/pages | "R151-61"xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/title | "ACE2 and ANG-(1-7) in the rat uterus during early and late gestation."xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://purl.uniprot.org/core/volume | "294"xsd:string |
| http://purl.uniprot.org/citations/17977916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17977916 |
| http://purl.uniprot.org/citations/17977916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17977916 |
| http://purl.uniprot.org/uniprot/Q5EGZ1#attribution-5E24308C719672D04F3BD64F72322FCC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17977916 |
| http://purl.uniprot.org/uniprot/P47820#attribution-5E24308C719672D04F3BD64F72322FCC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17977916 |
| http://purl.uniprot.org/uniprot/P01015#attribution-5E24308C719672D04F3BD64F72322FCC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17977916 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JXU8-mappedCitation-17977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977916 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MXV4-mappedCitation-17977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977916 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZYL1-mappedCitation-17977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977916 |
| http://purl.uniprot.org/uniprot/#_A0A8L2UK05-mappedCitation-17977916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17977916 |