| http://purl.uniprot.org/citations/17978469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17978469 | http://www.w3.org/2000/01/rdf-schema#comment | "Since 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has reproductive and developmental toxicity as an estrogen antagonist, we investigated the effects of TCDD on osteogenesis in rat skeleton and the human female-responsive osteoblastic osteosarcoma cell line SaOS-2. Rat fetuses were exposed to 5, 10, or 15 microg/kg TCDD on gestation day (GD) 10. TCDD dose-dependently induced single or multiple rat fetal skeletal development malformations in vivo. In vitro, 10 nM TCDD significantly inhibited cell proliferation in the presence of 1 microM 17-beta-estradiol (E2) in SaOS-2 cells. Insulin-like growth factor binding protein 6 (IGFBP-6), as a crucial regulator in IGF system, plays an important role in osteogenesis and bone function. TCDD (15 microg/kg) induced a dramatic 3-fold increase in IGFBP-6 mRNA expression in rat fetal calvaria on GD 21. On the other hand, the concurrent treatment of 10 nM TCDD and 1 muM E2 resulted in a significant increase in IGFBP-6 mRNA and protein after 24 h in SaOS-2 cells, but TCDD and (or) E2 had no effect on the mRNA level of cytosolic aromatic hydrocarbon receptor. The functional estrogen-responsive element (ERE) [5'-CCT TCA CCT G-3'] (-9 to +1) in the IGFBP-6 promoter region was identified in this study for the first time as the ER genomic binding site. Collectively, these results suggest that TCDD can alter the expression of IGFBP-6 gene and exerts growth-inhibitory effects on osteogenesis. In addition, TCDD exhibits an anti-estrogenic effect through its interference with the binding of activated estrogen-liganded ER to the functional ERE in IGFBP-6 gene promoter."xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.org/dc/terms/identifier | "doi:10.1248/bpb.30.2018"xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/author | "Zhang S.L."xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/author | "Sun Z.J."xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/author | "Zhao Y.Y."xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/author | "Zhao Y.Y.'"xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/name | "Biol Pharm Bull"xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/pages | "2018-2026"xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/title | "Toxic effects of TCDD on osteogenesis through altering IGFBP-6 gene expression in osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/17978469 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17978469 |
| http://purl.uniprot.org/citations/17978469 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17978469 |
| http://purl.uniprot.org/uniprot/#_P24592-mappedCitation-17978469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17978469 |
| http://purl.uniprot.org/uniprot/#_Q9H2B5-mappedCitation-17978469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17978469 |
| http://purl.uniprot.org/uniprot/P24592 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17978469 |
| http://purl.uniprot.org/uniprot/Q9H2B5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17978469 |