| http://purl.uniprot.org/citations/17981124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17981124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17981124 | http://www.w3.org/2000/01/rdf-schema#comment | "SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases (SENPs). The physiologic consequences of SUMOylation and deSUMOylation are not fully understood. Here we investigate the phenotypes of mice lacking SENP1 and find that SENP1(-/-) embryos show severe fetal anemia stemming from deficient erythropoietin (Epo) production and die midgestation. We determine that SENP1 controls Epo production by regulating the stability of hypoxia-inducible factor 1alpha (HIF1alpha) during hypoxia. Hypoxia induces SUMOylation of HIF1alpha, which promotes its binding to a ubiquitin ligase, von Hippel-Lindau (VHL) protein, through a proline hydroxylation-independent mechanism, leading to its ubiquitination and degradation. In SENP1(-/-) MEFs, hypoxia-induced transcription of HIF1alpha-dependent genes such as vascular endothelial growth factor (VEGF) and glucose transporter 1 (Glut-1) is markedly reduced. These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.08.045"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.08.045"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Cheng J."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Kang X."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Kang X."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Yeh E.T.H."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/author | "Yeh E.T.H."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/pages | "584-595"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/pages | "584-595"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/title | "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/title | "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia."xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/17981124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17981124 |
| http://purl.uniprot.org/citations/17981124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17981124 |