| http://purl.uniprot.org/citations/17981133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17981133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17981133 | http://www.w3.org/2000/01/rdf-schema#comment | "The COPII vesicular coat forms on the endoplasmic reticulum from Sar1-GTP, Sec23/24 and Sec13/31 protein subunits. Here, we define the interaction between Sec23/24.Sar1 and Sec13/31, involving a 40 residue Sec31 fragment. In the crystal structure of the ternary complex, Sec31 binds as an extended polypeptide across a composite surface of the Sec23 and Sar1-GTP molecules, explaining the stepwise character of Sec23/24.Sar1 and Sec13/31 recruitment to the membrane. The Sec31 fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 and Sec23 residues at the Sar1 GTPase active site explains how GTP hydrolysis is triggered leading to COPII coat disassembly. The Sec31 active fragment is accommodated in a binding groove supported in part by Sec23 residue Phe380. Substitution of the corresponding residue F382L in human Sec23A causes cranio-lenticulo-sutural dysplasia, and we suggest that this mutation disrupts the nucleation of COPII coat proteins at endoplasmic reticulum exit sites."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.10.006"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.10.006"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/author | "Goldberg J."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/author | "Goldberg J."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/author | "Bi X."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/author | "Bi X."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/author | "Mancias J.D."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/author | "Mancias J.D."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/pages | "635-645"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/pages | "635-645"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/title | "Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/title | "Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31."xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/17981133 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17981133 |
| http://purl.uniprot.org/citations/17981133 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17981133 |
| http://purl.uniprot.org/citations/17981133 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17981133 |
| http://purl.uniprot.org/citations/17981133 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17981133 |