| http://purl.uniprot.org/citations/17982059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17982059 | http://www.w3.org/2000/01/rdf-schema#comment | "The effector immune mechanisms underlying peanut-induced anaphylaxis remain to be fully elucidated. We investigated the relative contribution of Igs, mast cells (MCs), and FcepsilonRI in the elicitation of anaphylaxis in a murine model. Assessment of peanut hypersensitivity reactions was performed clinically and biologically. Our data show that wild-type (WT; C57BL/6 strain) mice consistently developed severe anaphylaxis (median clinical score: 3.5/5), an approximately 8 degrees C drop in core body temperature, and significantly increased plasma levels of histamine and leukotrienes. CD40 ligand- and B cell-deficient mice presented evidence of allergic sensitization as demonstrated by production of Th2-associated cytokines by splenocytes and a late-phase inflammatory response that were both indistinguishable to those detected in WT mice. However, CD40 ligand- and B cell-deficient mice did not exhibit any evidence of anaphylaxis. Our data also show that MC-deficient (Kit(W)/Kit(W-v)) mice did not suffer, unlike their littermate controls, anaphylactic reactions despite the fact that serum levels of peanut-specific Igs were similarly elevated. Finally, FcepsilonRI-deficient mice experienced anaphylactic responses although to a significantly lesser degree than those observed in WT mice. Thus, these data demonstrate that the presence of peanut-specific Abs along with functional MCs comprise a necessary and sufficient condition for the elicitation of peanut-induced anaphylaxis. That the absence of FcepsilonRI prevented the development of anaphylaxis only partially insinuates the contribution of an IgE-independent pathway, and suggests that strategies to impair MC degranulation may be necessary to improve the efficacy of anti-IgE therapy."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.10.6696"xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Reed J."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Walker T."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Coyle A.J."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Jordana M."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Alvarez D."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Fattouh R."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Goncharova S."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Waserman S."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/author | "Arias K."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/pages | "6696-6703"xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/title | "Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses."xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17982059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17982059 |
| http://purl.uniprot.org/citations/17982059 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17982059 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXC5-mappedCitation-17982059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982059 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-17982059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982059 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-17982059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982059 |
| http://purl.uniprot.org/uniprot/#_A4ZVL1-mappedCitation-17982059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982059 |