| http://purl.uniprot.org/citations/17982081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17982081 | http://www.w3.org/2000/01/rdf-schema#comment | "Although studies indicate LIGHT (lymphotoxin (LT)-like, exhibits inducible expression and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) enhances inflammation and T cell-mediated immunity, the mechanisms involved in this process remain obscure. In this study, we assessed the role of LIGHT in IL-12 production and development of CD4(+) Th cells type one (Th1) in vivo. Bone marrow-derived dendritic cells from LIGHT(-/-) mice were severely impaired in IL-12p40 production following IFN-gamma and LPS stimulation in vitro. Furthermore, blockade of LIGHT in vitro and in vivo with HVEM-Ig and LT beta receptor (LTbetaR)-Ig leads to impaired IL-12 production and defective polyclonal and Ag-specific IFN-gamma production in vivo. In an infection model, injection of HVEM-Ig or LTbetaR-Ig into the usually resistant C57BL/6 mice results in defective IL-12 and IFN-gamma production and severe susceptibility to Leishmania major that was reversed by rIL-12 treatment. This striking susceptibility to L. major in mice injected with HVEM-Ig or LTbetaR-Ig was also reproduced in LIGHT(-/-) --> RAG1(-/-) chimeric mice. In contrast, L. major-infected LTbeta(-/-) mice do not develop acute disease, suggesting that the effect of LTbetaR-Ig is not due to blockade of membrane LT (LTalpha1beta2) signaling. Collectively, our data show that LIGHT plays a critical role for optimal IL-12 production by DC and the development of IFN-gamma-producing CD4(+) Th1 cells and its blockade results in severe susceptibility to Leishmania major."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.10.6901"xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Liu D."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Xu G."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Fu Y.X."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Korner H."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Kung S.K."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Uzonna J.E."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/author | "Okwor I."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/pages | "6901-6909"xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/title | "LIGHT Is critical for IL-12 production by dendritic cells, optimal CD4+ Th1 cell response, and resistance to Leishmania major."xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17982081 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17982081 |
| http://purl.uniprot.org/citations/17982081 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17982081 |
| http://purl.uniprot.org/uniprot/P41155#attribution-4BE9139952ED1C9DC687BDB01D9F9A51 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17982081 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-17982081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982081 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA2-mappedCitation-17982081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982081 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA8-mappedCitation-17982081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982081 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P889-mappedCitation-17982081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982081 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6M8-mappedCitation-17982081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982081 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7D5-mappedCitation-17982081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17982081 |