| http://purl.uniprot.org/citations/17984088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17984088 | http://www.w3.org/2000/01/rdf-schema#comment | "Restriction of glutamine synthetase to the nervous system is mainly achieved through the mutual function of the glucocorticoid receptor and the neural restrictive silencing factor, NRSF/REST. Glucocorticoids induce glutamine synthetase expression in neural tissues while NRSF/REST represses the hormonal response in non-neural cells. NRSF/REST is a modular protein that contains two independent repression domains, at the N and C termini of the molecule, and is dominantly expressed in nonneural cells. Neural tissues express however splice variants, REST4/5, which contain the repression domain at the N, but not at the C terminus of the molecule. Here we show that full-length NRSF/REST or its C-terminal domain can inhibit almost completely the induction of gene transcription by glucocorticoids. By contrast, the N-terminal domain not only fails to repress the hormonal response but rather stimulates it markedly. The inductive activity of the N-terminal domain is mediated by hBrm, which is recruited to the promoter only in the concomitant presence of GR. Importantly, a similar inductive activity is also exerted by the splice variant REST4. These findings raise the possibility that NRSF/REST exhibits a dual role in regulation of glutamine synthetase. It represses gene induction in nonneural cells and enhances the hormonal response, via its splice variant, in the nervous system."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m707366200"xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Thiel G."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Rousso T."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Vardimon L."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Dror V."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Abramovitz L."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Ben-Dror I."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Blau L."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Granot L."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Landoy E."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/author | "Shapira T."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/pages | "110-119"xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/title | "Dual role of NRSF/REST in activation and repression of the glucocorticoid response."xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/17984088 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17984088 |
| http://purl.uniprot.org/citations/17984088 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17984088 |
| http://purl.uniprot.org/uniprot/Q13127#attribution-195C885575E79BB84CD1F246F47E7BDC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17984088 |
| http://purl.uniprot.org/uniprot/P51531#attribution-195C885575E79BB84CD1F246F47E7BDC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17984088 |