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http://purl.uniprot.org/citations/17984573http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17984573http://www.w3.org/2000/01/rdf-schema#comment"Adiponectin is an adipocytokine that is involved in insulin sensitivity. The adiponectin gene contains a single nucleotide polymorphism (SNP) at position 276 (G/T). The GG genotype of SNP276 (G/T) is associated with lower plasma adiponectin levels and a higher insulin resistance index. Therefore, we examined the influence of SNP276 (G/T) on the plasma level of adiponectin in response to exercise training. Thirty healthy Japanese (M12/F18; 56 to 79 years old) performed both resistance and endurance training, 5 times a week for 6 months. The work rate per kg of weight at double-product break-point (DPBP) was measured. Blood samples were obtained before and after the experiment. Plasma concentrations of adiponectin, HbA1c, insulin, glucose, total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, and triglyceride were measured. Genotypes of SNP276 were specified. Student's t-test for paired values and unpaired values was used. After the 6-month training period, the work rate per kg of weight at DPBP and the plasma HDL-cholesterol level were significantly improved (P<0.05), while no change was observed in the total plasma adiponectin level. However, the plasma adiponectin level in those with the GT + TT genotype had significantly increased (P<0.05). Additionally, the degree of the decrease in the HOMA-R level was significantly greater in the subjects with the GT + TT genotype than those with the GG genotype (p<0.05). Our results suggest that subjects with the genotype GT + TT at SNP276 (G/T) have a greater adiponectin-related response to exercise training than those with the GG genotype."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.org/dc/terms/identifier"doi:10.1507/endocrj.k06-146"xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Huang H."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Maeda S."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Murakami H."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Otsuki T."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Saito Y."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Kuno S."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Sone H."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Iemitsu M."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Ajisaka R."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/author"Tada Iida K."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/name"Endocr J"xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/pages"879-886"xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/title"Influence of adiponectin gene polymorphism SNP276 (G/T) on adiponectin in response to exercise training."xsd:string
http://purl.uniprot.org/citations/17984573http://purl.uniprot.org/core/volume"54"xsd:string
http://purl.uniprot.org/citations/17984573http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17984573
http://purl.uniprot.org/citations/17984573http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17984573
http://purl.uniprot.org/uniprot/#_A8K660-mappedCitation-17984573http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17984573
http://purl.uniprot.org/uniprot/#_B2R773-mappedCitation-17984573http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17984573
http://purl.uniprot.org/uniprot/#_Q15848-mappedCitation-17984573http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17984573
http://purl.uniprot.org/uniprot/B2R773http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17984573
http://purl.uniprot.org/uniprot/A8K660http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17984573