| http://purl.uniprot.org/citations/17986005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17986005 | http://www.w3.org/2000/01/rdf-schema#comment | "The receptor tyrosine kinase Ror2 plays important roles in mediating non-canonical Wnt5a signaling by activating the Wnt-JNK pathway and inhibiting the beta-catenin-TCF pathway. It has been shown that Ror2 is phosphorylated and activated by casein kinase Iepsilon when both molecules are over-expressed in cultured cells. However, it remains unknown whether or not Ror2 is phosphorylated upon Wnt5a stimulation. Here we show that Ror2 is phosphorylated on serine/threonine residues upon stimulation of cultured cells, expressing Ror2 endogenously, with Wnt5a, but not Wnt3a. It was found that treatment of cells with glycogen synthase kinase-3 (GSK-3) inhibitors (LiCl and SB216763) or small interfering RNAs (siRNAs) for GSK-3 (mainly GSK-3alpha) can inhibit Wnt5a-induced phosphorylation of Ror2. Immunoprecipitated Ror2 can also be phosphorylated by purified GSK-3alpha or GSK-3betain vitro, and ectopic co-expression of Ror2 and GSK-3 (mainly GSK-3alpha) in cultured cells results in Ror2 phosphorylation, irrespective of Wnt5a, that is sensitive to SB216763. These results indicate that GSK-3 is involved in Wnt5a-induced phosphorylation of Ror2. Moreover, it was found that Wnt5a-induced cell migration can be inhibited by SB216763 or by siRNA-mediated suppression of GSK-3alpha (and GSK-3beta) expression, further emphasizing the role(s) of GSK-3 in Wnt5a-induced signaling."xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2007.01128.x"xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/author | "Minami Y."xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/author | "Nishita M."xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/author | "Kikuchi A."xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/author | "Yoo S.K."xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/pages | "1215-1223"xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/title | "Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2."xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/17986005 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17986005 |
| http://purl.uniprot.org/citations/17986005 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17986005 |
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| http://purl.uniprot.org/uniprot/Q2NL51#attribution-C060EF699603A04BA934DF8CB1DDC524 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17986005 |
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| http://purl.uniprot.org/uniprot/#_P22725-mappedCitation-17986005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17986005 |