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| http://purl.uniprot.org/citations/17986384 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell to cell interaction is one of the key processes effecting angiogenesis and endothelial cell function. Wnt signalling is mediated through cell-cell interaction and is involved in many developmental processes and cellular functions. In this study, we investigated the possible function of Wnt5a and the non-canonical Wnt pathway in human endothelial cells. We found that Wnt5a-mediated non-canonical Wnt signalling regulated endothelial cell proliferation. Blocking this pathway using antibody, siRNA or a down-stream inhibitor led to suppression of endothelial cell proliferation, migration, and monolayer wound closure. We also found that the mRNA level of Wnt5a is up-regulated when endothelial cells are treated with a cocktail of inflammatory cytokines. Our findings suggest non-canonical Wnt signalling plays a role in regulating endothelial cell growth and possibly in angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.10.166"xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/author | "Smith S.K."xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/author | "Yeh J.C."xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/author | "Cheng C.W."xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/author | "Charnock-Jones D.S."xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/author | "Fan T.P."xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/pages | "285-290"xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/title | "Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration."xsd:string |
| http://purl.uniprot.org/citations/17986384 | http://purl.uniprot.org/core/volume | "365"xsd:string |
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