| http://purl.uniprot.org/citations/17988630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17988630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17988630 | http://www.w3.org/2000/01/rdf-schema#comment | "Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a splice variant of the thousand and one amino acid protein kinase 2, cloned here by virtue of its binding to the arcadlin intracellular domain. TAO2beta is a MAPKKK that activates the MEK3 MAPKK, which phosphorylates the p38 MAPK. Activation of p38 feeds-back on TAO2beta, phosphorylating a key serine required for triggering endocytosis of N-cadherin at the synapse. Arcadlin knockout increases the number of dendritic spines, and the phenotype is rescued by siRNA knockdown of N-cadherin. This pathway of regulated endocytosis of N-cadherin via protocadherin/TAO2beta/MEK3/p38 provides a molecular mechanism for transducing neuronal activity into changes in synaptic morphologies."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.08.020"xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.08.020"xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Sakurai T."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Sakurai T."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Tanaka H."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Yamagata K."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Yamagata K."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Sakaguchi T."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Sakaguchi T."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Okamura K."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Okamura K."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Yasuda S."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Yasuda S."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Mizoguchi A."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Mizoguchi A."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Sugiura H."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Sugiura H."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "De Robertis E.M."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "De Robertis E.M."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Tran U."xsd:string |
| http://purl.uniprot.org/citations/17988630 | http://purl.uniprot.org/core/author | "Tran U."xsd:string |