| http://purl.uniprot.org/citations/17988665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17988665 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon-alpha (IFN-alpha) induces apoptosis in some cell types and promotes cell survival in other cell types, but the molecular mechanisms underlying distinct IFN-alpha-induced cell behaviours remain poorly understood. In the present study, we show that IFN-alpha induced the cellular FLICE (FADD-like interleukin-1 beta-converting enzyme) inhibitory protein (c-FLIP), which serves as a promoter of cell survival in human B lymphoma cells. IFN-alpha induction of transient upregulation of c-FLIP was partially abrogated by the NF-kappaB inhibitor BAY11-7082 (BAY). Pretreatment with BAY sensitized both Daudi and U266 cells to the IFN-alpha-induced loss of mitochondrial membrane potential (DeltaPsi(m)). IFN-alpha phosphorylated the PKC isoform PKCalpha at a threonine residue, and the PKCalpha/betaI inhibitor Go6976 abrogated upregulation of IFN-alpha-induced NF-kappaB activity, leading to sensitization of cells to IFN-alpha-induced apoptosis. To analyze the role of PKCalpha in the IFN-alpha-induced signaling, Daudi cells overexpressing a constitutively active mutant of PKCalpha (caPKCalpha) were used. The caPKCalpha-expressing Daudi cells were partially resistant to the IFN-alpha-induced loss of DeltaPsi(m), concomitant with elevated levels of c-FLIP protein. Together, these results demonstrate that IFN-alpha causes a transient upregulation of c-FLIP expression, at least through PKCalpha-mediated activation of NF-kappaB. The balance between IFN-alpha-induced pro-apoptotic and survival signals determines the cell fate. Thus, therapeutic intervention in this balance may be effective for treatment of patients with IFN-alpha-refractory tumours."xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2007.10.001"xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/author | "Mizuguchi J."xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/author | "Hayashida M."xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/author | "Hoshika A."xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/author | "Kanetaka Y."xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/author | "Yanase N."xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/pages | "246-254"xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/title | "Interferon-alpha induces transient upregulation of c-FLIP through NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/17988665 | http://purl.uniprot.org/core/volume | "314"xsd:string |
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