| http://purl.uniprot.org/citations/17988935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17988935 | http://www.w3.org/2000/01/rdf-schema#comment | "Hsp70 has been shown to act as a chaperone and be associated with cytoprotection against DNA damage caused by environmental stresses. However, it is unknown whether genetic variation in HSP70 plays a role in stress tolerance and cytoprotection against DNA damage. We determined the frequencies of three polymorphisms, HSP70-1 G190C, HSP70-2 G1267A, and HSP70-hom T2437C from 251 steel-plant workers exposed to coke-oven emission and 130 controls. We estimated the association between the HSP70variants/haplotypes and the levels of DNA damage in their peripheral blood lymphocytes detected by single-cell gel electrophoresis assay. Our results showed that overall coke-oven workers had higher levels of the Olive tail moment (Olive TM) (1.27+/-1.12) than that of the controls (0.56+/-0.99, P<0.001). Coke-oven workers with the HSP70-1 C/C genotype had higher levels of Olive TM (2.19+/-0.65), compared with HSP70-1 G/C and G/G carriers (Olive TM=1.34+/-1.09 and 1.14+/-1.08, respectively, P=0.022 and 0.003, respectively). However, the HSP70-2 G1267A and HSP70-hom T2437C polymorphisms were not associated with the levels of Olive TM (P=0.929 and 0.795, respectively). Haplotype analysis showed that carriers of TCG/TCG haplotype pairs had the highest levels of Olive TM among both the exposed subjects (2.04+/-0.59) and the controls (0.81+/-0.59). Our results suggest that the individuals with the homozygous HSP70-1 C/C genotype among the coke-oven workers may be susceptible to DNA damage."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mrgentox.2007.09.004"xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Bai Y."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Liang H."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Su J."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Tan H."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/author | "Tanguay R.M."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/name | "Mutat Res"xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/pages | "221-229"xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/title | "Association between heat-shock protein 70 gene polymorphisms and DNA damage in peripheral blood lymphocytes among coke-oven workers."xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://purl.uniprot.org/core/volume | "649"xsd:string |
| http://purl.uniprot.org/citations/17988935 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17988935 |
| http://purl.uniprot.org/citations/17988935 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17988935 |
| http://purl.uniprot.org/uniprot/#_B4DH02-mappedCitation-17988935 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17988935 |