| http://purl.uniprot.org/citations/17992475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17992475 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocyte growth factor (HGF), its transmembrane tyrosine kinase receptor (c-Met), and urokinase type plasminogen activator (uPA) is a key protein in the plasminogen activation system, which plays a proteolytically important role in the invasion and metastasis of various types of cancers. However, the mechanisms by which HGF/c-Met signaling mediates cancer progression and metastasis are unclear. This study was designed to investigate the roles of HGF/c-Met in tumor progression and metastasis in HepG2 and Hep3B hepatoma cell lines. Treatment with HGF increased c-Met phosphorylation in a dose-dependent manner. Activity of c-Met phosphorylation peaked 1-3 min after HGF treatment and then declined. HGF enhanced the protein level and the activity of uPA in HepG2 and Hep3B cells, and the uPAR protein level also increased in a HGF dose-dependent manner. HGF increased cell invasion through the Matrigel. A monoclonal antibody against human uPA receptor, mAb 3936, inhibited HGF-mediated tumor cell invasion in a dose-dependent manner. Down-regulation of uPA using uPA-shRNA induced a decrease in in vitro cell invasion. These results suggest that hepatoma cells express functional c-Met, which may provide a target for a therapeutic basis to interfere with metastases of cancer cells by inhibiting uPA system-mediated proteolysis."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10585-007-9106-6"xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Lee D.S."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Kim H.G."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Kim J.R."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Choi E.Y."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Yoon S.S."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Hyun M.S."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Jang B.I."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Kim T.N."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/author | "Eun J.Y."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/name | "Clin Exp Metastasis"xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/pages | "89-96"xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/title | "Role of hepatocyte growth factor/c-Met signaling in regulating urokinase plasminogen activator on invasiveness in human hepatocellular carcinoma: a potential therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/17992475 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17992475 |
| http://purl.uniprot.org/citations/17992475 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17992475 |
| http://purl.uniprot.org/uniprot/#_C9WSJ3-mappedCitation-17992475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17992475 |
| http://purl.uniprot.org/uniprot/#_C9WSJ4-mappedCitation-17992475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17992475 |
| http://purl.uniprot.org/uniprot/#_A5D6Q9-mappedCitation-17992475 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17992475 |