| http://purl.uniprot.org/citations/17993611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17993611 | http://www.w3.org/2000/01/rdf-schema#comment | "Although detection of autoantibodies in the peripheral blood from patients with immune-mediated endothelial dysfunctions has so far failed to provide tools of diagnostic or pathogenetic value, putative bioindicators include anti-endothelial cell antibodies, a heterogeneous family of antibodies that react with autoantigens expressed by endothelial cells. In this study, to identify endothelial autoantigens involved in the autoimmune processes causing endothelial damage, we screened a human microvascular endothelial cell cDNA library with sera from patients with Behçet's disease. We identified antibodies to the C-terminus of Ral binding protein1 (RLIP76), a protein that catalyzes the ATP-dependent transport of glutathione (GSH) conjugates including GSH-4-hydroxy-t-2,3-nonenal, in the serum of a significant percentage of patients with various diseases characterized by immune-mediated endothelial dysfunction, including Behçet disease, systemic sclerosis, systemic lupus erythematosus and carotid atherosclerosis. These autoantibodies increased intracellular levels of 4-hydroxy-t-2,3-nonenal, decreased levels of GSH and activated C-Jun NH2 Kinase signaling (JNK), thus inducing oxidative stress-mediated endothelial cell apoptosis. The dietary antioxidant alpha-tocopherol counteracted endothelial cell demise. These findings suggest that autoantibodies to RLIP76 play a pathogenetic role in immune-mediated vascular diseases and represent a valuable peripheral blood bioindicator of atherosclerosis and immune-mediated vascular diseases."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-05-092825"xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Malorni W."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Matarrese P."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Alessandri C."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Conti F."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Delunardo F."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Margutti P."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Ortona E."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Profumo E."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Rigano R."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Siracusano A."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Sorice M."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Valesini G."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Garofalo T."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Capozzi A."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Colasanti T."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/author | "Salvati B."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/pages | "4559-4570"xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/title | "Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/17993611 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17993611 |