| http://purl.uniprot.org/citations/17995939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17995939 | http://www.w3.org/2000/01/rdf-schema#comment | "Close homolog of L1 (CHL1) is a transmembrane cell adhesion molecule with unique developmental functions in cortical neuronal positioning and dendritic projection within the L1 family, as well as shared functions in promotion of integrin-dependent neurite outgrowth and semaphorin3A (Sema3A)-mediated axon repulsion. The molecular mechanisms by which CHL1 mediates these diverse functions are obscure. Here it is demonstrated using a cytofluorescence assay that CHL1 is able to recruit ezrin, a member of the ezrin-radixin-moesin (ERM) family of filamentous actin binding proteins to the plasma membrane, and that this requires a membrane-proximal motif (RGGKYSV) in the CHL1 cytoplasmic domain. This sequence in CHL1 is shown to have novel functions necessary for Sema3A-induced growth cone collapse and CHL1-dependent neurite outgrowth and branching in cortical embryonic neurons. In addition, stimulation of haptotactic cell migration and cellular adhesion to fibronectin by CHL1 depends on the CHL1/ERM recruitment motif. These findings suggest that a direct or indirect interaction between CHL1 and ERM proteins mediates Sema3A-induced growth cone collapse as well as neurite outgrowth and branching, which are essential determinants of axon guidance and connectivity in cortical development."xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2007.05013.x"xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/author | "Maness P.F."xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/author | "Buhusi M."xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/author | "Schlatter M.C."xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/author | "Wright A.G."xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/pages | "731-744"xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/title | "CHL1 promotes Sema3A-induced growth cone collapse and neurite elaboration through a motif required for recruitment of ERM proteins to the plasma membrane."xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17995939 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17995939 |
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| http://purl.uniprot.org/uniprot/#_P26040-mappedCitation-17995939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17995939 |
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