| http://purl.uniprot.org/citations/17996262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17996262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17996262 | http://www.w3.org/2000/01/rdf-schema#comment | "The considerable diversity of Conus peptides in the I(1)-superfamily provides a rare opportunity to define parameters important for the post-translational l-to d-isomerization of amino acids. This subtlest of post-translational modifications is not readily detectable by most techniques, and it would be a considerable advance if one could predict its potential occurrence purely from gene sequences. We previously described three I(1)-conotoxins, iota-RXIA (formerly designated r11a), r11b and r11c, each containing a d-amino acid at the third position from the C-terminus. In this work, we investigated two novel I(1)-superfamily members, r11d and ar11a, which we show have only l-amino acids. Based on these observations and an analysis of cDNA sequences of other group members, we suggest that there is a rule to predict d-amino acids in I(1)-superfamily peptides. Two factors are important: the residue to be modified should be three amino acids from the C-terminus of the precursor sequence, and it should be in a suitable sequence context. We apply the rule to other members of the I(1)-superfamily, to determine a priori which are probably modified."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2007.09.006"xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2007.09.006"xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Morrison A."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Morrison A."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Imperial J.S."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Imperial J.S."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Watkins M."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Watkins M."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Yoshikami D."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Yoshikami D."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Buczek O."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/author | "Buczek O."xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/pages | "218-229"xsd:string |
| http://purl.uniprot.org/citations/17996262 | http://purl.uniprot.org/core/pages | "218-229"xsd:string |