| http://purl.uniprot.org/citations/17998401 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17998401 | http://www.w3.org/2000/01/rdf-schema#comment | "A long-standing biological question is how a eukaryotic cell controls the size of its nucleus. We report here that in fission yeast, nuclear size is proportional to cell size over a 35-fold range, and use mutants to show that a 16-fold change in nuclear DNA content does not influence the relative size of the nucleus. Multi-nucleated cells with unevenly distributed nuclei reveal that nuclei surrounded by a greater volume of cytoplasm grow more rapidly. During interphase of the cell cycle nuclear growth is proportional to cell growth, and during mitosis there is a rapid expansion of the nuclear envelope. When the nuclear/cell (N/C) volume ratio is increased by centrifugation or genetic manipulation, nuclear growth is arrested while the cell continues to grow; in contrast, low N/C ratios are rapidly corrected by nuclear growth. We propose that there is a general cellular control linking nuclear growth to cell size."xsd:string |
| http://purl.uniprot.org/citations/17998401 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200708054"xsd:string |
| http://purl.uniprot.org/citations/17998401 | http://purl.uniprot.org/core/author | "Nurse P."xsd:string |
| http://purl.uniprot.org/citations/17998401 | http://purl.uniprot.org/core/author | "Neumann F.R."xsd:string |
| http://purl.uniprot.org/citations/17998401 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17998401 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17998401 | http://purl.uniprot.org/core/pages | "593-600"xsd:string |
| http://purl.uniprot.org/citations/17998401 | http://purl.uniprot.org/core/title | "Nuclear size control in fission yeast."xsd:string |
| http://purl.uniprot.org/citations/17998401 | http://purl.uniprot.org/core/volume | "179"xsd:string |
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