| http://purl.uniprot.org/citations/18003833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18003833 | http://www.w3.org/2000/01/rdf-schema#comment | "Collapsin response mediator protein 1 (CRMP1) is one of the CRMP family members that mediates signal transduction of axonal guidance and neuronal migration. We show here evidence that CRMP1 is involved in semaphorin3A (Sema3A)-induced spine development in the cerebral cortex. In the cultured cortical neurons from crmp1+/-mice, Sema3A increased the density of clusters of synapsin I and postsynaptic density-95, but this increase was markedly attenuated in crmp1-/-mice. This attenuation was also seen in cyclin-dependent kinase 5 (cdk5)-/-neurons. Furthermore, the introduction of wild-type CRMP1 but not CRMP1-T509A/S522A, (Thr 509 and Ser 522 were replaced by Ala), a mutant that cannot be phosphorylated by Cdk5, into crmp1-/-neurons rescued the defect in Sema3A responsiveness. The Golgi-impregnation method showed that the crmp1-/-layer V cortical neurons showed a lower density of synaptic bouton-like structures and that this phenotype had genetic interaction with sema3A. These findings suggest that Sema3A-induced spine development is regulated by phosphorylation of CRMP1 by Cdk5."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3463-07.2007"xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Goshima Y."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Taniguchi M."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Usui H."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Uchida Y."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Nakamura F."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Morita A."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Honnorat J."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Kolattukudy P."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Yamashita N."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/author | "Thomasset N."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/pages | "12546-12554"xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/title | "Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1."xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/18003833 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18003833 |
| http://purl.uniprot.org/citations/18003833 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18003833 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDL3-mappedCitation-18003833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18003833 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTX5-mappedCitation-18003833 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18003833 |