| http://purl.uniprot.org/citations/18003977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18003977 | http://www.w3.org/2000/01/rdf-schema#comment | "The Fcgamma receptor FcRn transports immunoglobulin G (IgG) so as to avoid lysosomal degradation and to carry it bidirectionally across epithelial barriers to affect mucosal immunity. Here, we identify a calmodulin-binding site within the FcRn cytoplasmic tail that affects FcRn trafficking. Calmodulin binding to the FcRn tail is direct, calcium-dependent, reversible, and specific to residues comprising a putative short amphipathic alpha-helix immediately adjacent to the membrane. FcRn mutants with single residue substitutions in this motif, or FcRn mutants lacking the cytoplasmic tail completely, exhibit a shorter half-life and attenuated transcytosis. Chemical inhibitors of calmodulin phenocopy the mutant FcRn defect in transcytosis. These results suggest a novel mechanism for regulation of IgG transport by calmodulin-dependent sorting of FcRn and its cargo away from a degradative pathway and into a bidirectional transcytotic route."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e07-07-0658"xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Claypool S.M."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Lencer W.I."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Blumberg R.S."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Wagner J.S."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Hershberg R."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Dickinson B.L."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Borawski J.A."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Venu N."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Aiken M.L."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "D'Angelo J.A."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Pierce A.T."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/author | "Yen E.H."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/pages | "414-423"xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/title | "Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway."xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/18003977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18003977 |
| http://purl.uniprot.org/citations/18003977 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18003977 |
| http://purl.uniprot.org/uniprot/#_A0A024QZI2-mappedCitation-18003977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18003977 |
| http://purl.uniprot.org/uniprot/#_A0A1W6R2Y2-mappedCitation-18003977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18003977 |
| http://purl.uniprot.org/uniprot/#_A0A1W6R2Z1-mappedCitation-18003977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18003977 |