| http://purl.uniprot.org/citations/18005716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18005716 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18005716 | http://www.w3.org/2000/01/rdf-schema#comment | "Human ESCRT-I is a multiprotein complex that plays essential roles in HIV budding and endosomal protein sorting. All ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit of yeast ESCRT-I was recently identified (Mvb12p). We now demonstrate that two related human proteins (MVB12A and MVB12B) constitute the fourth class of metazoan ESCRT-I subunits, despite lacking identifiable sequence homology to Mvb12p. Hydrodynamic studies indicate that soluble human ESCRT-I complexes contain one copy of each of the four subunit types. MVB12 subunits associate with the core region of the binary TSG101-VPS37 complex through conserved C-terminal sequence elements. Both MVB12 depletion and overexpression inhibit HIV-1 infectivity and induce unusual viral assembly defects, including aberrant virion morphologies and altered viral Gag protein processing. Taken together, these studies define the composition of human ESCRT-I complexes and indicate that the MVB12 subunits play a unique role in regulating ESCRT-mediated virus budding."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2007.06.003"xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2007.06.003"xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Morita E."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Morita E."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Sundquist W.I."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Sundquist W.I."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Eckert D.M."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Eckert D.M."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Sandrin V."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Sandrin V."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Alam S.L."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/author | "Alam S.L."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/pages | "41-53"xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/pages | "41-53"xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/title | "Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding."xsd:string |
| http://purl.uniprot.org/citations/18005716 | http://purl.uniprot.org/core/title | "Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding."xsd:string |