| http://purl.uniprot.org/citations/18006696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18006696 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of B-cell receptor (BCR)-mediated survival signals in diffuse large B-cell lymphoma (DLBCL) remains undefined. Ligand-induced BCR signaling induces receptor oligomerization, Igalpha/beta immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation, and activation of the spleen tyrosine kinase (SYK), which initiates downstream events and amplifies the initial BCR signal. BCRs also transmit low-level tonic survival signals in the absence of receptor engagement. Herein, we assess the role of SYK-dependent tonic BCR survival signals in DLBCL cell lines and primary tumors and evaluate the efficacy of an ATP-competitive inhibitor of SYK, R406, in vitro. R406 induced apoptosis of the majority of examined DLBCL cell lines. In R406-sensitive DLBCL cell lines, R406 specifically inhibited both tonic- and ligand-induced BCR signaling (autophosphorylation of SYK525/526 and SYK-dependent phosphorylation of the B-cell linker protein [BLNK]). The majority of examined primary DLBCLs also exhibited tonic- and ligand-induced BCR signaling; in these primary tumors, BCR signaling was also inhibited by R406. Of note, BCR-dependent and R406-sensitive DLBCL cell lines were independently identified as "BCR-type" tumors by transcriptional profiling. Therefore, SYK-dependent tonic BCR signaling is an important and potentially targetable survival pathway in some, but not all, DLBCLs. In addition, R406-sensitive DLBCLs can be identified by their transcriptional profiles."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-07-100115"xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Monti S."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Kutok J.L."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Juszczynski P."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Shipp M.A."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Daley J."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Witzig T.E."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/author | "Habermann T.M."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/pages | "2230-2237"xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/title | "SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma."xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://purl.uniprot.org/core/volume | "111"xsd:string |
| http://purl.uniprot.org/citations/18006696 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18006696 |
| http://purl.uniprot.org/citations/18006696 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18006696 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH25-mappedCitation-18006696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18006696 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH73-mappedCitation-18006696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18006696 |
| http://purl.uniprot.org/uniprot/#_A0A075B6P5-mappedCitation-18006696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18006696 |
| http://purl.uniprot.org/uniprot/#_A0A075B6S6-mappedCitation-18006696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18006696 |
| http://purl.uniprot.org/uniprot/#_P0CF74-mappedCitation-18006696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18006696 |
| http://purl.uniprot.org/uniprot/#_P0CG04-mappedCitation-18006696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18006696 |